Tribro-OmicsVARIANT & PATIENT BROWSER
chr12:25,398,266 · KRAS · ACMG Pathogenic

Genomic intelligence platform

The Variant & Patient Browser

One enterprise workspace for clinical genomics — patient registries, variant interpretation, curated gene panels, ClinVar gene views, automated ACMG verdicts, AI interpretation and functional predictions.

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Millions
variants, real-time
ACMG
auto-classification
AI
powered by Claude
HIPAA
/ GDPR ready
app.tribro-omics.com / analytics
312
PATIENTS
4.6M
VARIANTS
1,284
PATHOGENIC
187
DIAGNOSED

Inside the browser

Every module, at a glance

From patient registry to single-variant verdict — here is how each screen of the browser looks.

/ patients
PATIENTDXSEQ
TBO-P0012DxWES
TBO-P0034UndxWGS
TBO-P0055DxPanel
TBO-P0070UndxWGS
Module 01

Patient Browser

Searchable registry with phenotype, diagnosis, sample & consent tracking.

/ variants
AllPathogenicVUSBenign
TP53Pathogenic
BRCA1Pathogenic
MLH1Likely path.
POLGVUS
Module 02

Variant Explorer

Filter millions of variants by gene, ACMG, ClinVar, frequency & in-silico scores.

/ panels
CARDIOVASCULAR · 3 PANELS
Cardiomyopathy
24 genes
OpenSet active
Marfan & Thoracic Aortic
15 genes
OpenSet active
Module 03 · new

Gene Panels

Curated clinical panels, ACMG SF list, custom builds or PanelApp import — set as active scope.

/ gene / KRAS
Gene KRAS · ClinVar (hg19)
200
Shown
22
Path
67
Uncertain
46
Benign
Module 04 · new

Gene / ClinVar View

Live myvariant.info gene summary, constraint, protein function & variant distribution.

/ variant / verdict
Uncertain significance+1 pts
BENIGNVUSPATHOGENIC
PM2 absent from gnomAD
PP5 reported in ClinVar
BP7 synonymous, no splice
Module 05 · new

Variant Verdict · ACMG

Automated ACMG/AMP points model with transparent, evidence-linked criteria.

/ variant / ai
AI interpretationpowered by Claude
Model: Claude · Sonnet — ask follow-up questions or switch models.
Module 06 · new

AI Interpretation

One-click plain-language variant write-up grounded in the annotation profile.

/ variant / predictions
CADD
Damaging
REVEL
Damaging
SIFT
Damaging
PolyPhen-2
Damaging
M-CAP
Damaging
AlphaMissense
Possibly
MutAssessor
Possibly
FATHMM
Tolerated
DANN
Damaging
18/19 predictors call this deleterious
Module 07 · new

Functional Predictions

dbNSFP in-silico panel — CADD, REVEL, SIFT, PolyPhen, AlphaMissense and more.

/ cohorts
Rare Disease — Pediatric
148
PATIENTS
2.1M
VARIANTS
Hereditary Cancer Panel
96
PATIENTS
412K
VARIANTS
Module 08

Cohort Explorer

Saved cohorts with disease, sex, age distributions and variant burden.

/ gene / TP53
TP53 · lollipop · 393 aa
Module 09

Gene Dashboard

Per-gene overview, protein domains and a carrier-count variant lollipop.

/ analytics
59.9%
Yield
4
Cohorts
Module 10

Analytics Dashboard

Program KPIs, diagnostic yield, classification mix and discovery trends.

/ report
Clinical Variant Report
Patient TBO-P0012 · TP53 c.743G>A
Pathogenic
Module 11

Clinical Reporting

One-click PDF clinical, variant, family & research reports with ACMG evidence.

Everything included

One platform, every workflow

🧬

Variant Interpretation

ACMG automation (PVS1/PS/PM/PP/BA/BS/BP) with ClinVar, OMIM, HGMD, PanelApp, GenCC & Orphanet evidence.

👪

Pedigree & Family

Interactive pedigrees for AD, AR, de novo, X-linked and mitochondrial inheritance.

🤖

AI Prioritization

Phenotype similarity, gene–disease validity, segregation & literature into an explainable score.

🧭

Genome Browser

GRCh37/38 with RefSeq, Ensembl, ClinVar, gnomAD, GTEx, regulatory & conservation tracks.

🔬

Multi-Omics

Genomics, transcriptomics, proteomics, epigenomics & metabolomics with networks & pathways.

🔒

Enterprise Security

HIPAA / GDPR ready, role-based access, MFA, encryption and full audit logging.

See the browser on your own data

Request access for a guided walkthrough with your cohorts, or talk to our team about deployment, security and integration.

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